Once-Weekly Insulins with Julia Mader
Why switch from once-daily to once-weekly basal insulin? Julia Mader discusses recent data on Insulin icodec and
Insulin efsitora from the ONWARDS-6 and QWINT-2 trials. What does the latest evidence say about which patient
groups might benefit from this new class of insulin? And what about hypoglycaemia?
Literature mentioned in the episode:
- Russell-Jones D, Babazono T, Cailleteau R, Engberg S, Irace C, Kjaersgaard MIS, Mathieu C, Rosenstock J, Woo V, Klonoff DC. Once-weekly insulin icodec versus once-daily insulin degludec as part of a basal-bolus regimen in individuals with type 1 diabetes (ONWARDS 6): a phase 3a, randomised, open-label, treat-to-target trial. Lancet. 2023 Nov 4;402(10413):1636-1647. doi: 10.1016/S0140-6736(23)02179-7.
- Wysham C, Bajaj HS, Del Prato S, Franco DR, Kiyosue A, Dahl D, Zhou C, Carr MC, Case M, Firmino Gonçalves L; QWINT-2 Investigators. Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment. N Engl J Med. 2024 Sep 10. doi: 10.1056/NEJMoa2403953.