Read the paper that inspired Dr Nauck
Yki-Ja¨rvinen H, Ryysy L, Nikkila¨K, Tulokas T, Vanamo R, Heikkila¨M. Comparison of Bedtime Insulin Regimens in Patients with Type 2 Diabetes Mellitus. A Randomized, Controlled Trial. Ann Intern Med. 1999; March (130:5): 389-396.
http://pubmed.ncbi.nlm.nih.gov/10068412/