Cardiovascular health and diabetes

Module 7: Heart failure on trial – DAPA-HF and EMPEROR-Reduced

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CME Credits: 1
Module duration: 1 hour
Launch date: Spring 2021 (version 1)
Updated: Autumn 2022 (version 2)
Expiry date: March 2027
Audience: Cardiologists (Subspeciality), Diabetes and Metabolism Specialists (Subspeciality), Endocrinologists (Subspeciality), General Physicians (Subspeciality), Public Health Physicians (Subspeciality)

My name is Miles Fisher and I’m a diabetologist in Glasgow and an Honorary Professor at the University of Glasgow. SGLT-2 inhibitors are now routine treatment for type 2 diabetes and in cardiovascular outcome trials it was observed that there was a reduction in hospitalisation for heart failure. We now have two finished trials looking at heart failure populations. The first trial was called DAPA-HF. This was presented at the EASD in 2019 and was published and this was the use of dapagliflozin in patients with heart failure. The most recent trial was called EMPEROR-Reduced and this was using empagliflozin in patients with heart failure.

This module focuses on two recent trials that investigated the use of SGLT-2 inhibitors in patients with heart failure: EMPEROR-Reduced (which looked at empagliflozin) and DAPA-HF (which studied dapagliflozin). The module sets out the background to the trials and their design and assesses how their results might be applied to clinical practice.

Learning Outcomes

By the end of this module, you will be able to:

Explain the rationale for investigating the efficacy and safety of treatment with SGLT-2 inhibitors in patients with heart failure and a reduced ejection fraction, with or without diabetes

Identify the key features of the DAPA-HF and EMPEROR-Reduced clinical trials

Apply the results of the DAPA-HF and EMPEROR-Reduced trials to the management of typical patients with diabetes


This module includes self-marked assessments, such as knowledge checks and/or case studies, as well as a marked final assessment, which you can attempt up to five times. To complete the module, you must review all chapters, pass the final assessment (80% pass mark), and fill in our feedback form.


Contributors

Professor
Miles Fisher
Author
Professor
John Wilding
Expert Reviewer
Assessment Setter
Assessment Setter