Real-world evidence

Module 1: An introduction to real-world evidence

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CME Credits: 1.5
Module duration: 1.5 hours
Launch date: Autumn 2021 (version 1)
Updated: -
Expiry date: March 2027

Hello ladies and gentlemen. My name is Marc Evans. I’m a diabetologist based at the University Hospital of Llandough in Cardiff. Over the years, I’ve developed an interest in analysis of real-world evidence, generation of real-world data and have published fairly widely in this field. I have also developed an interest in how these data may be used to support health economic evaluations and have contributed to a variety of health technology appraisals using such approaches. It is with great pleasure that I’m with you to discuss some of the educational benefits of understanding the intricacies and relevance of real-world data, as it translates to our daily practice and our management of people with diabetes in 2020 and beyond.

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To introduce our course on real-world evidence (RWE), this module outlines recent developments in the role attributed to RWE by research institutions around the world, focusing in particular on the value of RWE as compared to evidence from randomised controlled trials (RCTs). After surveying considerations for the design of RWE studies, the module concludes with some examples of RWE, exploring how these might be applied to clinical practice in the care of people with diabetes.

Learning Outcomes

By the end of this module, you will be able to:

Summarise the advantages of real-world evidence (RWE) studies, particularly as compared to randomised controlled trials (RCTs)

Explain the critical design elements required to minimise bias and confounding in RWE studies

Make use of data from RWE studies in typical clinical scenarios


This module includes self-marked assessments, such as knowledge checks and/or case studies, as well as a marked final assessment, which you can attempt up to five times. To complete the module, you must review all chapters, pass the final assessment (80% pass mark), and fill in our feedback form.


Contributors

Author, Assessment Setter
Professor
Apostolos Tsapas
Expert Reviewer