SGLT-2 inhibitors

Module 2: Efficacy and safety of SGLT-2 inhibitors

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CME Credits: 1
Module duration: 1 hour
Launch date: Winter 2023 (version 1)
Updated: -
Expiry date: March 2027
Audience: Diabetes and Metabolism Specialists (Subspeciality), Endocrinologists (Subspeciality)

Hello. I’m David Matthews and I’m Emeritus Professor of Diabetes Medicine from the University of Oxford. And today I’m going to be talking about SGLT-2 inhibitors, their efficacy and safety. So, this module explores some of the key Phase 3 efficacy and safety data from a number of different trials on canagliflozin, dapagliflozin, ertugliflozin and empagliflozin – either as a monotherapy or in conjunction with other oral antidiabetic drugs and/or insulin. The associated advantages and adverse events are discussed and data from real-world evidence studies are introduced.

This module explores some of the key Phase 3 efficacy and safety data from a number of different trials on canagliflozin, dapagliflozin and empagliflozin either as a monotherapy or in conjunction with other oral antidiabetic drugs and/or insulin. The associated advantages and adverse events are discussed and data from real-world evidence studies are introduced.

Davies MJ, Aroda VR, Collins BS, Gabbay RA, Green J, Maruthur NM, Rosas SE, Del Prato S, Mathieu C, Mingrone G, Rossing P, Tankova T, Tsapas A, Buse JB. Management of Hyperglycaemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia 2022; 65, pages1925–1966.
http://link.springer.com/article/10.1007/s00125-022-05787-2

Assessment will rely in part on learners having read the following article referenced in this module.

Learning Outcomes

By the end of this module, you will be able to:

Explain the key efficacy data from the Phase 3 trials of SGLT-2 inhibitors in people with type 2 diabetes

Identify the safety and adverse event profile of SGLT-2 inhibitors in people with type 2 diabetes

Apply current guidelines to typical patients with type 2 diabetes who may benefit from treatment with SGLT-2 inhibitors as an adjunct to other therapies for type 2 diabetes


This module includes self-marked assessments, such as knowledge checks and/or case studies, as well as a marked final assessment, which you can attempt up to five times. To complete the module, you must review all chapters, pass the final assessment (80% pass mark), and fill in our feedback form.


Contributors

Professor (Emeritus)
David Matthews
Author
Professor
Roopa Mehta
Expert Reviewer
Assessment Setter
Assessment Setter