GLP-1 receptor agonists

Module 2: GLP-1 and cardiovascular disease

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CME Credits: 1
Module duration: 1 hour
Launch date: Autumn 2020 (version 1)
Updated: Autumn 2022 (version 2)
Expiry date: March 2027
Audience: Cardiologists (Subspeciality), Diabetes and Metabolism Specialists (Subspeciality), Endocrinologists (Subspeciality)

Hello. My name is Tina Vilsbøll. I am a Professor at the University of Copenhagen in Denmark. I work at Gentofte Hospital, which is part of the Steno Diabetes Center, Copenhagen. I have the honour of talking to you today about GLP-1 and its effect on the cardiovascular system and cardiovascular disease.

In this module, we take a closer look at the role GLP-1 plays in the cardiovascular system and the therapeutic potential of GLP-1 receptor agonists (GLP-1RAs) to improve cardiovascular outcomes in people with type 2 diabetes.

Buse JB, Wexler DJ, Tsapas A, Rossing P, Mingrone G, Mathieu, D’Alessio DA, Davies MJ. 2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. Volume 63, pages 221– 228(2020).
http://pubmed.ncbi.nlm.nih.gov/31857443/

Learning Outcomes

By the end of this module, you will be able to:

Explain the multifactorial basis for increased risk of cardiovascular disease (CVD) and reduced life expectancy in type 2 diabetes

Explain the various physiological mechanisms by which GLP-1 receptor agonists might affect the course of CVD in people with type 2 diabetes and the potential role of GLP-1 receptor agonists in preventing atherosclerosis

Plan how GLP-1 receptor agonists can be used in the management of type 2 diabetes to reduce the risk of CVD


This module includes self-marked assessments, such as knowledge checks and/or case studies, as well as a marked final assessment, which you can attempt up to five times. To complete the module, you must review all chapters, pass the final assessment (80% pass mark), and fill in our feedback form.


Contributors

Professor
Tina Vilsbøll
Author, Assessment Setter
Professor
Filip Knop
Expert Reviewer
Assessment Setter