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Horizons   >   News   >   SLENDO Wrap Up

September 4, 2024 — 18:30 🕑 8 minutes

SLENDO Wrap Up

The global burden of diabetes is continually growing, which calls for enhanced collective action to prevent and treat diabetes complications. The Sri Lanka College of Endocrinology, the European Association for the Study of Diabetes and the International Society of Endocrinology joined forces at the Sri Lanka Endocrine Congress (SLENDO) 2024 to promote excellence in diabetes care and research.

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Video transcript

My name is Caterina Conte. I'm a professor of medicine at San Raffaele Roma University in Rome, and I do my clinical practice and research activities at IRCCS MultiMedica in Milan, Italy, as well. And I'd say the overarching goal of this collaboration is to support the medical community in addressing critical areas and to promote excellence in diabetes care and research. This collaboration between the EASD and the Sri Lanka College of Endocrinologists for SLENDO 2024 Congress was rooted in our mutual commitment to addressing the significant and growing challenge of diabetes in the Southeastern Asian region and globally, in general, for the burden of diabetes continues to grow, underscoring the need for greater collective action. And this partnership was focussed on sharing knowledge that can lead to improved diagnosis, management and prevention of diabetes complications, importantly, without placing blame on people living with diabetes. I gave two presentations at SLENDO 2024. And in these presentations, I addressed two key topics: incretin-based therapies and the mechanisms of SGLT2 inhibitors. For the first talk on incretin-based therapies, I focussed on the long-term benefits and safety of these drugs, which are paramount in the context of long-term use. And the discussion centred on how incretin-based therapies provide sustained glycaemic control with added cardiovascular and renal benefits. And I also touched upon the potential risks of excess loss of muscle mass during weight loss, which is a hot topic now and a crucial consideration when managing patients over time. In the other session, the one on SGLT2 inhibitors, so these drugs have significantly improved cardiovascular and renal outcomes, leading to major shifts in the medical management of several categories of patients. And this is similar somehow to how statins revolutionised the cardiovascular care by reducing the risks associated with atherosclerotic disease. There are several potential mechanisms. Not all of them have been clarified so far, but, for sure, there is, of course, the glucose lowering action, which is very important in the context of diabetes management, but is not the only mechanism of action. There is also a reduction in the preload, as, for example, in heart failure. So this is also important. And it looks like there are additional mechanisms, such as the reduction of oxidative stress, and also the natriuresis, of course, and the diuretic effects of these drugs. So there are several potential mechanisms that underlie the benefits of these drugs that are, actually, difficult to summarise in just a few minutes. However, as also Chantal Mathieu highlighted in a discussion we had on this topic, a discussion we had on this topic, while SGLT2 inhibitors are generally well tolerated and relatively safe they do have some side effects that require consideration. And, although rare, there are some potentially serious risks, such as euglycaemic ketoacidosis. So it is very important for healthcare providers to be aware and inform patients about these potential risks to ensure informed decision-making and also safety. The hospitality was very warm and we were immersed in local traditions, and the interaction with our hosts was great. And so this also added a rich cultural dimension to the scientific exchange. And this combination made really SLENDO 2024 a memorable experience to me. And I was really, really honored and happy to have the opportunity to participate in this conference.

SLENDO 2024 was held from 8th to 11th August, 2024, in Colombo, Sri Lanka, and was organised by the Sri Lanka College of Endocrinology (SLCE) in collaboration with the International Society of Endocrinology (ISE) and the European Association for the Study of Diabetes (EASD).


“The rationale for this collaboration is rooted in our mutual commitment to addressing the significant and growing challenge of diabetes in the South-Asian region and globally,” says EASD Early Career Academy Committee member Prof. Caterina Conte from San Raffaele Roma Open University (Rome, Italy).


She was one of four EASD representatives who presented at SLENDO 2024, the others being EASD President Prof. Chantal Mathieu (Leuven, Belgium), Prof. Apostolos Tsapas (Thessaloniki, Greece) and Prof. Lalantha Leelarathna (Manchester, UK).


The collaboration between these learned societies considerably enriched the programme of SLENDO 2024. EASD experts delivered key sessions on topics, such as novel glucose-monitoring techniques, advanced insulin-delivery methods and the expanding role of artificial intelligence in diabetes care. In addition, interactive workshops were held that proved highly successful.


 

SGLT2 inhibitors: Drugs with Multiple Benefits


In her first talk given at SLENDO 2024, Prof. Caterina Conte discussed long-term effects of incretin-based therapy. Her second presentation on mechanisms of action of SGLT2 inhibitors started with the development of these drugs, which dates back to the early 19th century. She discussed the mechanisms underlying their mode of action, as well as their cardiometabolic and renal benefits that extend to both people living with and without diabetes. “SGLT2 inhibitors have led to major shifts in the management of several categories of patients,” Prof. Caterina Conte says. Nevertheless, certain risks including euglycaemic ketoacidosis need to be taken into account when considering the long-term use of SGLT2 inhibitors.

Local Aspects and Global Perspectives

 

As Conte points out, the exchange between smaller diabetes societies and larger international organisations is mutually beneficial. “Local conferences often discuss region-specific issues, for example, the unique genetic, cultural and social factors that impact diabetes in this area.” These aspects can inform and enhance global strategies. On the other hand, the exchange facilitates local adaptation of the latest global research and novel perspectives.


“Collaborations foster a more comprehensive understanding of diabetes and ensure that care and research are more globally informed and locally impactful.”

 

 

 

Sri Lanka Endocrine Congress (SLENDO) 2024
Sri Lanka College of Endocrinology in collaboration with the International Society of Endocrinology and The European Association for the Study of Diabetes
Symposium “Expanding Horizons in SGLT2 Inhibition”
   •   Caterina Conte (Italy): Mechanisms of Effects of SGLT2i
   •   Chantal Mathieu (Belgium): Emerging Roles of SGLT2i in Diabetes
   •   Lalantha Leelarathna(UK): SGLT2i in Non-Diabetic Patients
Symposium “Incretins & Gut Peptides”
   •   Apostolos Tsapas (Greece): Evolution of Gut Peptide-Based Therapy in Diabetes –
        from Mono to Triple Agonism
   •   Chantal Mathieu (Belgium): Incretin Therapy in T1DM
   •   Lalantha Leelarathna(UK): Incretin-Based Therapy for Long Term Outcomes
 

 

To learn more about the SLENDO Congress, go to https://slendo.lk

 

Author: Judith Moser, MD. Any opinions expressed in this article are the responsibility of EASD e-Learning.

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