Harald Sourij recounts the significance of the UK Prospective Diabetes Study which was co-led by Rury R Holman, this year’s Banting Medal recipient. EASD President Chantal Mathieu highlights the brand-new for Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes, just published in Diabetologia. Furthermore, she then gives examples of precision medicine that will help us in understanding and treating it. Wrapping up the episode, Mathieu extends an invitation to the upcoming EASD Annual Meeting in Madrid this September.