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Type 1 diabetes is characterised by absolute insulin deficiency and signs of autoimmunity. You can detect circulating autoantibodies in the peripheral circulation before diagnosis. We have a genetic disease susceptibility, mostly defined by HLA genes, but in addition we have more than 50 genes conferring increased susceptibility outside the HLA region. Patients are prone to ketosis and ketoacidosis and the insulin deficiency can be detected by low C-peptide secretion.
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  • Absolute insulin deficiency
  • About half of the cases diagnosed in childhood
  • Signs of autoimmunity: circulating autoantibodies
  • HLA-conferred disease susceptibility
  • Prone to ketosis and ketoacidosis
  • Low C-peptide secretion