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When it comes to type 2 diabetes, the condition is much more complicated. First of all, there are many, many genetic variants that have been associated with type 2 diabetes. So far, we have identified something like over 130 different signals located in around 115 different loci. So, as you can imagine, it is not simple to link each one of these alterations with specific changes in protein function.
“Many genetic variants have been associated with type 2 diabetes. So far, we have identified over 130 signals located in 115 different loci”

 

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The above graphic is reproduced courtesy of Dr Miriam Udler, modified from Florez JC, Udler MS, Hanson RL. Genetics of Type 2 Diabetes. Chapter 14 in: Cowie CC, Casagrande SS, Menke A, Cissell MA, Eberhardt MS, Meigs JB, Gregg EW, Knowler WC, Barrett-Connor E, Becker DJ, Brancati FL, Boyko EJ, Herman WH, Howard BV, Narayan KMV, Rewers M, Fradkin JE, editors. Diabetes in America, Third Edition. Bethesda, MD, National Institutes of Health, NIH Pub No. 17-1468, 2018.

Legend
GWAS: genome-wide association study


Florez JC. Mining the Genome for Therapeutic Targets. Diabetes. 2017 Jul;66(7):1770-1778.
http://www.ncbi.nlm.nih.gov/pubmed/28603140