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The Non-Obese Diabetic (NOD) mouse model

  • Spontaneous diabetes
  • Insulitis
  • Gender difference in diabetes incidence
  • Defects in immune regulation
    (cytokine profile, T cell apoptosis, regulator cells)
We have the non-obese diabetic mouse model – the NOD mouse model – that gets a disease similar to type 1 diabetes in humans. It’s a spontaneous diabetes. There is inflammation in the islets called insulitis, but there is a gender difference in diabetes incidence, with female mice having more diabetes than male mice, a fact that we don’t see in humans. And also there are so many defects in the immune system of these mice, that they are much more diseased immunologically than humans with type 1 diabetes.
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