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So why is it so important to identify the specific genetic causes of diabetes? For a very simple reason. Because these causes are associated with specific guidance in terms of the selection of treatment. So, for instance, for someone with this condition, there may be no specific treatment, but for others we have an indication for using either a low dose of sulphonylureas or a high dose of sulphonylureas, and in others we have a specific indication for the use of metformin. So, there is a proper treatment for each one of these conditions. For these conditions are, to some extent, easy to treat, because they are the result of a specific monogenic defect.
“There is a proper treatment for each one of these conditions … because they are the result of a specific monogenic defect”

 

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Gloyn AL, Drucker DJ. Precision medicine in the management of type 2 diabetes. Lancet Diabetes Endocrinol. 2018 Nov;6(11):891-900.
http://www.ncbi.nlm.nih.gov/pubmed/29699867

Urakami T. Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment. Diabetes Metab Syndr Obes. 2019 Jul 8;12:1047-1056.

Udler MS, McCarthy MI, Florez JC, Mahajan A. Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine. Endocr Rev. 2019 Dec 1;40(6):1500-1520.